TTI-622, an investigational CD47 inhibitor, showed preliminary signs of clinical activity with a manageable safety profile among patients with relapsed/refractory lymphoma, according to findings

Cecilia Koskinen, Umeå. Lack of CD47 impairs bone cell differentiation and results in an osteopenic bone phenotype in vivo. 65 000 kronor.

Upregulation of CD47 is a host checkpoint response to pathogen recognition. CD47 is a ubiquitously immune-regulatory protein that is found on the surface of many cells in the body. It tells circulating immune cells called macrophages not to eat these cells by binding to phagocyte-expressed signal regulatory protein alpha (SIRPα). CD47 is found to be overexpressed on tumor cells and act as a don't eat me' signal, which contributes to immune evasion. Macrophages mediated phagocytosis via blockade CD47/SIRPα (signal regulatory protein alpha) interaction was proved to induce effective antitumor immune response. “There may be circumstances where host responses need boosting and CD47 represents a novel target for host-directed therapies in such cases,” the scientists write, mentioning SARS-CoV-2, HIV, HPV and Ebola virus among several possibilities. Article.

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CD47, also known as integrin-associated protein (IAP), ovarian cancer antigen OA3, Rh-related antigen and MER6, is a multispanning transmembrane receptor belonging to the immunoglobulin superfamily that is important in self-recognition, cell adhesion and survival, immune regulation, and cardiovascular physiology.

CD47 (also known as integrin associated protein) is a transmembrane protein that mainly functions as an anti-phagocytic or “do not eat me” signal, enabling CD47-expressing cells to evade phagocytic elimination by macrophages and other phagocytes. CD47 gene product. IAP, MER6, OA3. This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon Search results for CD47 at Sigma-Aldrich. Summary: This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix.

2020-11-12 · CD47 Antibody (B6H12) is available as both the non-conjugated anti-CD47 antibody form, as well as multiple conjugated forms of anti-CD47 antibody, including agarose, PE, FITC and multiple Alexa Fluor ® conjugates. CD47 is an integral membrane protein that plays a role in the regulation of cation fluxes across cell membranes.

Immunogen CD47 molecule Application Expression of CD47 (IAP, MER6, OA3) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. Summaries for CD47 gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Section: Entrez Gene summary for CD47 Gene: This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration CD47, also known as integrin-associated protein (IAP), ovarian cancer antigen OA3, Rh-related antigen and MER6, is a multispanning transmembrane receptor belonging to the immunoglobulin superfamily that is important in self-recognition, cell adhesion and survival, … cd47_human

This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. CD47 is cell surface protein that regulates the innate immune system by serving as an inhibitory signal for phagocytosis by macrophages, dendritic cells, and neutrophils.

It tells circulating immune cells called macrophages not to eat these cells by binding to phagocyte-expressed signal regulatory protein alpha (SIRPα). 2021-03-04 · CD47 is a cell surface glycoprotein expressed on a wide variety of cells.
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Intresset för CD47 bygger på People for CD47 Cancer Cure.
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December 6, 2020 — TTI-622, an investigational CD47 inhibitor, showed preliminary signs of clinical activity with a manageable safety profile among patients with relapsed/refractory lymphoma.

Bedömningsbilen med särskilt Inläst ur: 1. uppl. Stockholm : Bonnier Carlsen, 2016. Berättare: Johan Ulveson.

2021-01-26

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Article. M Caspi Tal et al. Upregulation of CD47 is a host checkpoint response to pathogen recognition. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells.